Cleveland Guardians in Preseason Top 500
Glossary for future grades: h-hit tool, p-power tool, s-speed tool, fb-fastball, sl-slider, cv-curveball, ch-change-up, ct-cutter, fv-future value overall.
| NO. | NAME | POS | B/T | FUTURE GRADES | LEVEL | AGE | ETA |
| 1 | Gavin Williams | SP | L/R | 70fb-60cv-55sl-50ch-60fv | AA | 23 | mid-2023 |
| 2 | Bo Naylor | C | L/R | 50h-50p-50s-55fv | MLB | 22 | early-2023 |
| 3 | George Valera | OF | L/L | 55h-55p-50s-55fv | AAA | 22 | early-2023 |
| 4 | Brayan Rocchio | SS | S/R | 55h-45p-60s-55fv | AAA | 22 | mid-2023 |
| 5 | Daniel Espino | SP | R/R | 70fb-55cv-65sl-50ch-55fv | AA | 22 | late-2023 |
| 6 | Tanner Bibee | SP | R/R | 60fb-60sl-50cv-50ch-55fv | AA | 24 | mid-2023 |
| 7 | Chase DeLauter | OF | L/L | 55h-60p-55s-50fv | n/a | 21 | 2025 |
| 8 | Cody Morris | SP | R/R | 60fb-55cv-55ch-50ct-50fv | MLB | 26 | now |
| 9 | Logan Allen | SP | R/L | 50fb-50sl-60ch-50fv | AAA | 24 | early-2023 |
| 10 | Angel Martinez | SS | S/R | 55h-45p-55s-50fv | AA | 21 | late-2023 |
| 11 | Will Brennan | OF | L/L | 55h-40p-55s-50fv | MLB | 25 | now |
| 12 | Jaison Chourio | OF | S/R | 55h-45p-55s-50fv | R (DSL) | 18 | 2026 |
| 13 | Jhonkensy Noel | 3B | R/R | 40h-60p-35s-45fv | AAA | 21 | mid-2023 |
| 14 | Tyler Freeman | SS | R/R | 60h-35p-50s-45fv | AAA | 24 | early-2022 |
| 15 | Gabriel Arias | SS | R/R | 45h-55p-50s-45fv | MLB | 23 | now |
| 16 | Joey Cantillo | SPRP | L/L | 50fb-45cv-60ch-45fv | AA | 23 | late-2023 |
| 17 | Justin Campbell | SP | L/R | 50fb-55cv-55ch-45fv | n/a | 22 | 2025 |
| 18 | Juan Brito | 2B | S/R | 55h-40p-40s-45fv | Low-A | 21 | 2025 |
| 19 | Jose Tena | 2B | L/R | 55h-45p-55s-45fv | AAA | 22 | mid-2023 |
| 20 | Xzavion Curry | SP | R/R | 55fb-45cv-50sl-45ch-45fv | AAA | 24 | early-2023 |
| 21 | Tanner Burns | SP | R/R | 55fv-55sl-55cv-50ch-45fv | AA | 24 | mid-2023 |
| 22 | Hunter Gaddis | SP | R/R | 50fb-45sl-60ch-45fv | AAA | 25 | mid-2023 |