Chicago Cubs in Preseason Top 500
Glossary for future grades: h-hit tool, p-power tool, s-speed tool, fb-fastball, sl-slider, cv-curveball, ch-change-up, ct-cutter, fv-future value overall.
| NO. | NAME | POS | B/T | FUTURE GRADES | LEVEL | AGE | ETA |
| 1 | Pete Crow-Armstrong | OF | L/L | 60h-45p-60s-60fv | High-A | 21 | 2024 |
| 2 | Kevin Alcantara | OF | R/R | 50h-55p-55s-55fv | Low-A | 20 | 2024 |
| 3 | Alexander Canario | OF | R/R | 45h-60p-50s-55fv | AAA | 23 | mid-2023 |
| 4 | Matt Mervis | 1B | L/R | 50h-60p-35s-55fv | AAA | 25 | early-2023 |
| 5 | Brennen Davis | OF | R/R | 50h-60p-50s-55fv | AAA | 23 | early-2023 |
| 6 | Cade Horton | SP | R/R | 60fb-50cv-65sl-50fv | n/a | 21 | 2025 |
| 7 | Cristian Hernandez | SS | R/R | 55h-55p-60s-50fv | R (ACL) | 19 | 2025 |
| 8 | Hayden Wesneski | SP | R/R | 60fb-60sl-50ch-50fv | MLB | 25 | now |
| 9 | Ben Brown | SP | R/R | 60fb-50cv-55sl-50fv | AA | 23 | mid-2023 |
| 10 | Jordan Wicks | SP | L/L | 55fb-45cv-55sl-65ch-45fv | High-A | 23 | 2024 |
| 11 | Owen Caissie | OF | L/R | 45h-55p-50s-45fv | High-A | 20 | 2024 |
| 12 | DJ Herz | SP | R/L | 55fb-50cv-65ch-45fv | High-A | 22 | 2024 |
| 13 | James Triantos | 3B | R/R | 60h-50p-50s-45fv | Low-A | 20 | 2025 |
| 14 | Jackson Ferris | SP | L/L | 60fb-55cv-55ch-45fv | n/a | 19 | 2026 |
| 15 | Caleb Kilian | SP | R/R | 60fb-55cv-55ct-50ch-45fv | AAA | 26 | early-2023 |
| 16 | Derniche Valdez | SS | R/R | 55h-55p-50s-45fv | n/a | 17 | 2027 |
| 17 | Jeremiah Estrada | RP | S/R | 70fb-50ch-50sl-45fv | MLB | 24 | now |
| 18 | Daniel Palencia | SPRP | R/R | 75fb-55cv-45ch-45fv | High-A | 23 | 2024 |
| 19 | Moises Ballesteros | C | L/R | 55h-45p-30s-45fv | Low-A | 18 | 2026 |
| 20 | Porter Hodge | SP | R/R | 55fb-50cv-60sl-45ch-45fv | High-A | 21 | 2024 |
| 21 | Miguel Amaya | C | R/R | 50h-50p-35s-45fv | AA | 23 | late-2022 |
| 22 | Ludwing Espinoza | SS | S/R | 55h-50p-50s-45fv | n/a | 17 | 2027 |